--- title: Cherwell | SAS Air Samplers in Pharmaceutical Development & Technology description: Academic Citation for SAS Air Samplers in Pharmaceutical Development & Technology image: https://www.cherwell-labs.co.uk/hubfs/pharmaceutical-development-technology-journal.jpg --- [![analytichem_Logo+claim_RGB](https://www.cherwell-labs.co.uk/hs-fs/hubfs/analytichem_Logo+claim_RGB.png?width=200&height=43&name=analytichem_Logo+claim_RGB.png "analytichem_Logo+claim_RGB")](https://www.cherwell-labs.co.uk/) [![Analytichem](https://www.cherwell-labs.co.uk/hs-fs/hubfs/analytichem_Logo+claim_RGB.png?width=200&height=56&name=analytichem_Logo+claim_RGB.png "Analytichem")](https://www.cherwell-labs.co.uk/) Search # SAS Air Samplers in Pharmaceutical Development & Technology ![](https://www.cherwell-labs.co.uk/hubfs/Marketplace/Cherwell%20Labs/imgs/icons/cherwell-icon-45.svg) *By Gill Power* ### SAS Microbial Air Sampler from Cherwell Laboratories Christopher Lee Albert Cherry, Huw Millward, Rose Cooper, John Landon reference the use of [SAS microbial air samplers](https://www.cherwell-labs.co.uk/microbial-air-samplers) in their paper ‘[A novel approach to sterile pharmaceutical freeze-drying](https://www.tandfonline.com/doi/abs/10.3109/10837450.2012.752388)’ published in Pharmaceutical Development and Technology. [![New Call-to-action](https://no-cache.hubspot.com/cta/default/2885977/d1a9d97e-c3ae-46e2-b72c-112a9c347d06.png)](https://cta-redirect.hubspot.com/cta/redirect/2885977/d1a9d97e-c3ae-46e2-b72c-112a9c347d06)   The following is an abstract from the article, which was published in January 2013:   **Abstract** A novel approach has been developed that enables sterile pharmaceutical products to be freeze-dried in the open laboratory without specialist facilities. The product is filled into vials, semi-stoppered and sealed inside one, followed by a second, sterilization pouch under class 100 conditions. The product is then freeze-dried in the laboratory where the vials are shelf-stoppered before being returned to class 100, unwrapped and crimped. The sterilization pouches increased the resistance to water vapor movement during sublimation, thereby increasing the sublimation time and product temperature. Ovine immunoglobulins were double wrapped and lyophilized (as above) adjusting the primary drying time and shelf temperature for increased product temperature and, therefore, prevention of collapse. Ovine immunoglobulin G formulations freeze-dried to ≤1.1% residual moisture with no effect on protein aggregation or biological activity. The process was simulated with tryptone soya broth and no growth of contaminating microbial cells was observed after incubation at 35 °C for 2 weeks. Although increasing lyophilization time, this approach offers significant plant and validation cost savings when sterile freeze-drying small numbers of vials thereby making the manufacture of treatments for neglected and orphan diseases more viable economically. Pharmaceutical Development and Technology is a MEDLINE-indexed journal publishing research in the design, development, manufacture, and evaluation of traditional and novel drug delivery systems, emphasising practical solutions and applications to theoretical and research-based problems.  We hope that you find this article an interesting read.  If you have used any Cherwell products during part of your research, we would like to hear details from you.   Comments ## Read other blog articles [ *By Gill Power* #### Specialist products for boosting microbial EM protocol reliability spotlighted by AnalytiChem UK at Pharmig 2025 ](https://www.cherwell-labs.co.uk/cherwell-labs-post/analytichem-uk-highlight-specialist-em-products-pharmig-2025-annual-conference) [ *By Gill Power* #### New AnalytiChem UK appointment strengthens customer focus and growth strategy ](https://www.cherwell-labs.co.uk/cherwell-labs-post/new-analytichem-uk-appointment-strengthens-customer-focus-and-growth-strategy) [ *By Gill Power* #### Cherwell announces Andy Whittard’s retirement and names Stuart Hall as new Managing Director ](https://www.cherwell-labs.co.uk/cherwell-labs-post/cherwell-announces-andy-whittards-retirement-stuart-hall-named-new-managing-director) ### Sign Up for our Blog We promise that we won't SPAM you. #### What's next #### Recent news [![Specialist products for boosting microbial EM protocol reliability spotlighted by AnalytiChem UK at Pharmig 2025](https://www.cherwell-labs.co.uk/hs-fs/hubfs/Redipor%20TwistLock%20Contact%20Plates%20with%20GS1%20DataMatrix%20Codes.png?width=50&height=50&name=Redipor%20TwistLock%20Contact%20Plates%20with%20GS1%20DataMatrix%20Codes.png) **Specialist products for boosting microbial EM protocol reliability spotlighted by AnalytiChem UK at Pharmig 2025** 10 November 2025 ](https://www.cherwell-labs.co.uk/cherwell-labs-post/analytichem-uk-highlight-specialist-em-products-pharmig-2025-annual-conference) [![New AnalytiChem UK appointment strengthens customer focus and growth strategy](https://www.cherwell-labs.co.uk/hs-fs/hubfs/Tom%20Pickford%20AnalytiChem%20UK%20Business%20Development%20Manager%20Midlands.jpg?width=50&height=50&name=Tom%20Pickford%20AnalytiChem%20UK%20Business%20Development%20Manager%20Midlands.jpg) **New AnalytiChem UK appointment strengthens customer focus and growth strategy** 20 October 2025 ](https://www.cherwell-labs.co.uk/cherwell-labs-post/new-analytichem-uk-appointment-strengthens-customer-focus-and-growth-strategy) #### Subscribe Receive the latest articles as they are published. #### Contact us Registered Office 7 & 8 Launton Business Centre, Murdock Road, Bicester, OX26 4XB **Phone** Tel: +44 (0) 1869 355 500 **Email** [sales.uk@analytichem.com](mailto:sales.uk@analytichem.com)    ![analytichem_Logo+claim_RGB](https://www.cherwell-labs.co.uk/hs-fs/hubfs/analytichem_Logo+claim_RGB.png?width=2000&height=431&name=analytichem_Logo+claim_RGB.png "analytichem_Logo+claim_RGB") ![BSI-ISO-9001-Certified-50px](https://www.cherwell-labs.co.uk/hs-fs/hubfs/BSI-ISO-9001-Certified-50px.png?width=130&height=77&name=BSI-ISO-9001-Certified-50px.png "BSI-ISO-9001-Certified-50px") AnalytiChem UK ©2025 (Formerly Cherwell) Reg. in England No: 01159518 VAT Reg. 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